Haphazardly dispersed atypical cells arrows have partially replaced normal lobular cells. Over time, the cells develop abnormalitities and continue accumulating atypical hyperplasia. Ductal breast cancer is thought to begin with abnormal tissue growth in a breast duct.
Atypical Hyperplasia: Section 4.a.
If there are microcalcifications discovered with lobular neoplasia, that can often indicate a higher risk for breast cancer development. For example, women diagnosed with atypical hyperplasia before age 45 seem to have a greater risk of developing breast cancer during their lifetimes. Journal of Clinical Oncology. Atypical hyperplasia of lobular hyperplasia breast breast is not a pre-malignant condition, in the way that cervical intra-epithelial neoplasia CIN is for cervical cancer.
Lobular Hyperplasia and neoplasia
New England Journal of Medicine. E-cadherin Mod Pathol ; Ductal breast cancer is thought to begin with abnormal tissue growth in a breast duct.